Read the lorazepam Results-at-a-Glance summary.

Status epilepticus (SE) is a serious condition that affects the brain. SE can be caused by medical conditions, illnesses, or injuries. A preferred treatment for SE is lorazepam. However, lorazepam is not approved by the FDA for children under 18 years old. This summary is for a study performed by the Pediatric Trials Network (PTN). The study was needed to find out how children with SE process lorazepam.

Read the oxcarbazepine Results-at-a-Glance summary.

Oxcarbazepine is a medicine that is approved by the U.S. Food and Drug Administration (FDA) for treating seizures in adults and children older than two years. However, guidance for children who have obesity was lacking. This study was needed to learn how a child’s obesity status affects the way they process oxcarbazepine.

Read diazepam Results-at-a-Glance summary.

Diazepam is a medicine approved by the U.S. Food and Drug Administration (FDA) for treating severe seizures in children. However, the most safe and effective dosage of diazepam for children was unknown.

Read rifampin Results-at-a-Glance summary.

Rifampin is an FDA approved antibiotic but has not been evaluated for treating staph infection in infants. The purpose of the study was to find out the pharmacokinetics and safety of rifampin in infants with suspected infections.

Read levetiracetam Results-at-a-Glance summary.

Levetiracetam is a medicine that is approved by the U.S. Food and Drug Administration (FDA) for treating seizures in children. However, it is unknown how well the medicine works in children who weigh more than average. These studies were needed to learn how children who are heavier than average weight process levetiracetam and the amount of the medicine they should receive when being treated for seizures.

Read sildenafil Results-at-a-Glance summary.

Infants born too early can get a lung disease called Bronchopulmonary dysplasia (BPD). Infants with BPD are likely to have pulmonary hypertension, a condition where the blood vessels in the lungs get blocked or destroyed, causing high blood pressure. Pulmonary hypertension increases the risk of death from BPD. There are no medicines approved by the U.S. Food and Drug Administration (FDA) for treating BPD. However, doctors often use the medicine sildenafil to manage high blood pressure in infants with BPD.