Read the clindamycin obesity Results-at-a-Glance summary.
Clindamycin is a medicine commonly used to treat a variety of infections, including skin and bone infections. Because the body easily absorbs clindamycin into fat, a child’s obesity status may affect the amount of the medicine they need to treat infections. Researchers performed this study to learn how children with obesity process clindamycin compared to children without obesity.
Read the topiramate Results-at-a-Glance summary.
Topiramate is a medicine used to treat seizures in adults and children. The recommended amount of topiramate children should receive is based on their weight. However, it was not known whether a child’s obesity status affects how they process topiramate.Researchers performed this study to learn how children with obesity process topiramate compared to children without obesity. They also wanted to learn the safest, most effective amount of the medicine they should receive.
Read the ondansetron Results-at-a-Glance summary.
Most breastfeeding women take at least one prescription medication. Some mothers worry that medicines they take might get into their breast milk and affect their baby. This study by the PTN, called Commonly used drugs during lactation and infant exposure (CUDDLE) was needed to learn how breastfeeding infants are exposed to medicine taken by breastfeeding women. Women who are breastfeeding may take ondansetron to treat nausea and vomiting.
Read the pantoprazole Results-at-a-Glance summary.
Pantoprazole is a medicine that is commonly used to treat gastroesophageal reflux disease (GERD). A child’s obesity status can change how they process the medicine. This study learned how children with obesity process pantoprazole compared to children without obesity.
Read the methadone Results-at-a-Glance summary.
Nearly 20% of children in the United States are classified as obese. These children receive medicines more often than children without obesity, and the doses of medicines they receive are often based on body weight. How obesity impacts the way children process medications was not well understood. The “Use of Physiologically-based Pharmacokinetic Modeling to Inform Dosing of the Opioid Analgesics Fentanyl and Methadone in Children with Obesity” study was conducted to learn how children’s age, obesity status, and genes impact the way their bodies process methadone and fentanyl.
Read the lorazepam Results-at-a-Glance summary.
Status epilepticus (SE) is a serious condition that affects the brain. SE can be caused by medical conditions, illnesses, or injuries. A preferred treatment for SE is lorazepam. However, lorazepam is not approved by the FDA for children under 18 years old. This summary is for a study performed by the Pediatric Trials Network (PTN). The study was needed to find out how children with SE process lorazepam.
Read the oxcarbazepine Results-at-a-Glance summary.
Oxcarbazepine is a medicine that is approved by the U.S. Food and Drug Administration (FDA) for treating seizures in adults and children older than two years. However, guidance for children who have obesity was lacking. This study was needed to learn how a child’s obesity status affects the way they process oxcarbazepine.
Read diazepam Results-at-a-Glance summary.
Diazepam is a medicine approved by the U.S. Food and Drug Administration (FDA) for treating severe seizures in children. However, the most safe and effective dosage of diazepam for children was unknown.
Read rifampin Results-at-a-Glance summary.
Rifampin is an FDA approved antibiotic but has not been evaluated for treating staph infection in infants. The purpose of the study was to find out the pharmacokinetics and safety of rifampin in infants with suspected infections.
Read levetiracetam Results-at-a-Glance summary.
Levetiracetam is a medicine that is approved by the U.S. Food and Drug Administration (FDA) for treating seizures in children. However, it is unknown how well the medicine works in children who weigh more than average. These studies were needed to learn how children who are heavier than average weight process levetiracetam and the amount of the medicine they should receive when being treated for seizures.
