Read the pantoprazole Results-at-a-Glance summary.

Pantoprazole is a medicine that is commonly used to treat gastroesophageal reflux disease (GERD). A child’s obesity status can change how they process the medicine. This study learned how children with obesity process pantoprazole compared to children without obesity.

Read the methadone Results-at-a-Glance summary.

Nearly 20% of children in the United States are classified as obese. These children receive medicines more often than children without obesity, and the doses of medicines they receive are often based on body weight. How obesity impacts the way children process medications was not well understood. The “Use of Physiologically-based Pharmacokinetic Modeling to Inform Dosing of the Opioid Analgesics Fentanyl and Methadone in Children with Obesity” study was conducted to learn how children’s age, obesity status, and genes impact the way their bodies process methadone and fentanyl.