The Pediatric Infectious Disease Journal • December 2016.
Ericson JE, Gostelow M, Autmizguine J, Hornik CP, Clark RH, Benjamin DK Jr, Smith PB; Pediatric Trials Network Executive Committee and Investigators.
Acyclovir is used to treat herpes simplex virus disease in infants. Treatment with high-dose acyclovir, 60 mg/kg/d, is recommended; however, the safety of this dosage has not been assessed in the past 15 years, and this dosage is not currently approved for infants by the US Food and Drug Administration. We included infants with neonatal herpes simplex virus disease treated with ≥14 days of intravenous acyclovir starting in the first 120 days of life admitted to 1 of 42 neonatal intensive care units managed by the Pediatrix Medical Group between 2002 and 2012.