Read the meropenem Results-at-a-Glance summary.

Infections in the intestines are common in premature infants younger than three months old. These infections are dangerous, and the infants often die. Meropenem is a medicine used to treat many different kinds of infections. It was approved for use in adults and older children, but until this study no one knew how the medicine affects infants younger than three months old.

Read the lisinopril Results-at-a-Glance summary.

Lisinopril is approved for treating high blood pressure in adults and children over 6 years old. But the best, safest dose of lisinopril in children under age 6 had never been figured out. High blood pressure is common in children and teens who have had a kidney transplant, but no one knew the correct dose for this group either.

Read the acyclovir Results-at-a-Glance summary.

Herpes simplex virus (HSV) is a dangerous infection that can often cause death or mental disability in infants. Acyclovir is a medicine approved by the U.S. Food and Drug Administration (FDA) for HSV but the best and safest dose of acyclovir for infants, particularly premature infants, was not previously known. The “Open-Label Study to Describe the Pharmacokinetics of Acyclovir in Premature Infants” study was conducted in order to learn more about the appropriate level of acyclovir dosing for infants.