Study evaluating pharmacokinetics of methadone administered through IV to healthy adults
Summary
This study will evaluate how healthy adults process methadone administered through IV. It is needed to determine the optimal dose of methadone and to understand variations in drug disposition. Methadone is already approved by the U.S. Food and Drug Administration for treatment of pain management and Opioid Use Disorder (OUD) in adults. Results from MTH02 will help update information on dosing methadone for adults, and they will lay the foundation for studies to label methadone for treating acute pain and OUD in children.
Publications
OVERVIEW
Status:
Enrollment completed
ClinicalTrials.gov identifier:
NCT05425420
Principal Investigator:
Kanecia Zimmerman, MD, MPH
Duke University School of Medicine Department of Pediatrics; Duke Clinical Research Institute
NEWS
- PTN Enrolls Participants in Methadone Study for AdultsThe Pediatric Trials Network (PTN) has enrolled the first participants in a study titled Pharmacokinetics, Pharmacodynamics, and Safety of a Single Dose Intravenous Methadone in Healthy Adult Volunteers (MTH02). This study will evaluate how healthy adults process methadone administered through IV. It is essential for determining the optimal dose of methadone and to understand variations in ...